Cyclic loading is an important stimulus for creating mechanically stable tissue engineered blood vessels. The goal of this work is to create a device that dynamically conditions rings of vascular tissue created by cells in culture without the use of a scaffold. To create a high-throughput and accurate yet inexpensive device, a regulated pressure source and electronic valve controller were utilized to cyclically inflate up to 32 ring segments cultured on a series of silicone tubes encased in standard sterile conical tubes. This device will be used to determine the dynamic culture conditions that optimize engineered vessel growth and maturation in culture.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Bullock, Samantha Lynn
• Ali, Haseeb
• Breindel, Jay Thomas
• Herrera, Jesse T.

Contributors

• Herrera, Jesse
• Shaw, Sharon
• Ali, Haseeb
• Hu, Jason
• Gwyther, Tracy

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043009-121244

Advisor

• Overstrom, Eric W.
• Billiar, Kristen
• Rolle, Marsha Whitney

Year

• 2009

Date created

• 2009-04-30

Resource type

• Major Qualifying Project

Major

• Mechanical Engineering
• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved

Last modified

• 2021-02-02