Adenoviruses are commonly used as gene vectors because of their low level of morbidity and ability to infect both dividing and non-dividing cells. Adenoviral expression systems in which a target gene is delivered to mammalian cells are commercially available. Here, I used one such system to individually express the genes of all dengue-2 virus proteins in an adenovirus, with the ultimate goal of infecting of primary dendritic cells. Through my work, I developed an optimized plan for future use of this system.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Bliven, Erin E.

Publisher

• Worcester Polytechnic Institute

Identifier

• 04D213M

Advisor

• Rulfs, Jill

Year

• 2004

Date created

• 2004-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright