Apoptosis is the major form of cell death in cholestatic liver disease. Our studies involved working with primary culture rat hepatocytes as a model for bile acid-induced hepatocyte injury during cholestatic liver disorders. The aim of this project was to investigate the role of hepatocyte attachment to various extracellular matrices in modulating the sensitivity to bile acid-induced apoptosis. Collagen type IV and fibronectin were found to protect against bile acid-induced apoptosis in hepatocytes.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tiber, Daniel Eric
• Silverio, Erika Lorraine

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D106M

Advisor

• Rulfs, Jill

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright