In C. elegans, the ras genes interact with mig-10 in regulation of neuron migration and excretory canal outgrowth. To characterize mutations in the 2 ras genes, mig-2 and cdc-42, marker transgenes were crossed into the mutant strains. The activated form of mig-2 caused a mild defect in excretory canal outgrowth. The deletion mutation in cdc-42 showed no defects in CAN migration or excretory canal outgrowth. A double mutant of mig-2(gm38) and mig-10(ct41) was also attempted to be constructed.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Dam, Toan Khanh

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D033M

Advisor

• Ryder, Elizabeth F.

Year

• 2005

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved