Student Work

Structure/Function Studies of EGFR Family and Kek1

Pubblico

The Epidermal Growth Factor Receptor (EGFR) family of tyrosine kinases play a key role in development and cancer. Kek1, a transmembrane protein, has been previously shown to inhibit the EGFR in Drosophila through its extracellular Domain V. To define structural elements of Domain V that mediate Kek1 binding, a phylogenetic analysis was carried out on Domain V, and five Domain V variants were designed to be tested for their ability to interact with Kek1.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • 23226
  • E-project-050621-160704
Award
Advisor
Year
  • 2021
Date created
  • 2021-05-06
Resource type
Major
Rights statement
Ultima modifica
  • 2023-01-19

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