Identification and Characterization of Differentially Expressed Genes During Listeria Monocytogenes Infection of Resistant and Susceptible MicePublic
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The goal of this MQP was to identify and characterize differentially expressed genes associated with Listeria monocytogenes infection in two strains of mice, BALB/cbyj (Listeria sensitive) and C57BL/6ByJ (Listeria resistant). We identified several genes both upregulated and deregulated by the host during infection, and mapped one gene's chromosomal location (though inconclusively) to gain a more complete understanding of the biochemical processes involved in the innate immune response.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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