Artemisinin, a secondary metabolite of A. annua, is a Sesquiterpene endoperoxide lactone. In other plants, sesquiterpene lactones have been found conjugated to other molecules. This project looked for the presence of AN conjugates through chemical and enzymatic hydrolysis. HPLC and TLC analysis were used to detect the presence of artemisinin released by these treatments. The initial data indicated that such conjugation may be present, but a more thorough evaluation in fact demonstrated that no AN was produced by treatments that would hydrolyze a number of commonly found in conjugated molecules.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Knapp, John Alexander

Publisher

• Worcester Polytechnic Institute

Identifier

• 01D253M

Advisor

• Wobbe, Kristin K.

Year

• 2001

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright