Menopause occurs because of declining levels of estrogen and puts women at risk for osteoporosis. Promensil, an over-the-counter medication containing phytoestrogens, is marketed to alleviate menopausal symptoms. The goal of this project was to look at the effects of Promensil and phytoestrogens on bone deposition, using a preosteoblast cell line and alkaline phosphatase activity as a marker of mineralization. Over five days, increasing concentrations of Promensil increased alkaline phosphatase activity in preosteoblast cells. Yet, cells indicated decreased confluence and cell viability at increasing Promensil concentrations.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Herman, Marine
• Griffin, Brigid
• Hartzel, Emma
• Makechnie, Kelly

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042822-101720
• 65036

Keyword

• Bone Health
• MQP
• Osteoblast
• Phytoestrogen
• Promensil
• Menopause

Advisor

• Rulfs, Jill
• Buckholt, Michael Allan

Year

• 2022

Date created

• 2022-04-28

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright