Opiates have been used for centuries to treat pain. The use of opiates on horses produces dysphoric side effects. The [mu]-receptor has been sequenced in five organisms. An equine cDNA library was created from horse brain. The use of rt-PCR to construct a probe of or clone directly the [mu]-receptor was ultimately unsuccessful. Once cloned, further experiments to elucidate the signal transduction pathway, distribution of receptor throughout the CNS, and binding kinetics may lead to more effective analgesics.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Bither, Jeremy Orin
• Walter, James Matthew

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D093M

Advisor

• Rulfs, Jill

Year

• 2000

Sponsor

• Tufts School of Veterinary Medicine

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright