"id" |"create_date" |"modified_date" |"depositor" |"title" |"date_uploaded" |"date_modified" |"state"|"proxy_depositor"|"on_behalf_of"|"arkivo_checksum"|"owner"|"alternate_title"|"award"|"includes"|"advisor" |"sponsor" |"center"|"year"|"funding"|"institute"|"school"|"major" |"sdg"|"note" |"alternative_title"|"label"|"relative_path"|"import_url"|"resource_type" |"creator" |"creator" |"contributor" |"description" |"abstract"|"keyword"|"license"|"rights_notes"|"rights_statement" |"access_right"|"publisher" |"date_created"|"subject"|"language"|"identifier" |"based_near"|"related_url"|"bibliographic_citation"|"source"|"version" |"permalink" "ns064805s"|"2020-01-17T12:26:42.130+00:00"|"2024-03-12T19:25:52.594+00:00"|"depositor@wpi.edu"|"A Novel Role of the p53 Tumor Suppressor Pathway in Maintaining Glucose Homeostasis"|"2020-01-17T07:26:41.592-05:00"|"2023-09-20T11:51:58.884-04:00"|"" |"" |"" |"" |"" |"" |"" |"" |"Adams, David S."|"UMass Med"|"" |"2010"|"" |"" |"" |"Biology & Biotechnology"|"" |"This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review."|"" |"" |"" |"" |"Major Qualifying Project"|"Franck, Debra-Ann"|"Tracy, Laura Ann"|"Sluss, Hayla"|"Type II diabetes is a disorder that affects the body's ability to produce or utilize insulin, and is characterized by hyperglycemia. The p53 tumor suppressor pathway has been shown to play a role in maintaining glucose homeostasis in a process mediated by Ser18. To better understand insulin resistance, we utilized a loss of p53 function model (phosphorylation mutant p53Ser23Ala) and a model where p53 is hyperactivated (model p44) to further define the role of p53 in insulin sensitivity in vivo. Insulin-mediated Akt activation was analyzed in tissues as a marker for insulin sensitivity. Glucose homeostasis was measured through glucose and insulin tolerance tests. It was found through these mouse models that p53 plays a vital role in regulating glucose homeostasis and insulin sensitivity."|"" |"" |"" |"" |"http://rightsstatements.org/vocab/InC/1.0/"|"" |"Worcester Polytechnic Institute"|"2010-04-28" |"" |"" |"E-project-042810-124821"|"" |"" |"" |"" |"W/"34c059c5d6169c34d752fe06b5bf702f4c2713ee""|"https://digital.wpi.edu/show/ns064805s"