Neuroprotective peptides NMI-9236 and NMI-8933 are drugs designed for emergency stroke treatment. Prior research indicated that the neurotrophic peptides upregulate Activator Protein-1, a transcription factor implicated in the neuroprotective function of the drugs. The purpose of this major qualifying project was to determine whether this upregulated particle is functional, i.e., capable of transcriptional trans-activation. The results indicate that the upregulated AP-1 is functional. These results contribute to the ongoing effort to elucidate the drugs' molecular mechanisms of action.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• El-Khishin, Adam

Publisher

• Worcester Polytechnic Institute

Identifier

• 99D146M

Advisor

• Adams, David S.

Year

• 1999

Date created

• 1999-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved