Student Work

Neurotrophic peptides that are therapeutic for strokes in a rat model upregulate enzymes which reduce oxidative stress in various tissues

Public

Downloadable Content

open in viewer

Neuroprotective peptides such as NMI-9236 are synthetic drugs designed for emergency stroke treatment. Prior research demonstrated that these peptides upregulate functional activator protein-1 (AP-1), which is a transcription factor thought to induce the gene expression of anti-oxidative enzymes. The purpose of this MQP was to investigate two aspects of these neurotrophic peptides. The first part was to determine if the upregulated AP-1 is capable of inducing trans-activation in a reporter plasmid. The second was to determine whether various peptides upregulate anti-oxidative enzymes as measured by Western blot analysis. The results indicate that AP-1 is indeed capable of trans-activation, and that anti-oxidative enzymes are upregulated in cell lines stimulated by various neurotrophic peptides.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • 00D284M
Advisor
Year
  • 2000
Date created
  • 2000-01-01
Resource type
Major
Rights statement
License

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/p5547v44j