Wound Healing Effects of a Modified Collagen-Binding Antimicrobial Peptide LL37Public
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Chronic wounds can often become infected due to bacterial resistance towards antibiotics and a new potential solution to this resistance is to use antimicrobial peptides (AMPs) to heal wounds. The goal of this project was to determine the wound healing ability of using antimicrobial peptides (AMPs) and modified collagen-binding AMPs on the ability of cells to migrate over in a bare area on a dish, simulating migration at the wound site, at varying AMP concentrations over time using scratch assays. In these assays, 3 peptides were studied for their ability to stimulate migration in human fibroblasts (CT 1005): human-derived AMP LL37, a modified synthetic LL37 with a collagen-binding domain (cCBD-LL37), and recombinant cCBD-LL37 produced and harvested from H1299 human lung carcinoma cells.
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