The compound poly--glutamic acid (-PGA) has been shown to have potential use as a drug delivery agent. In this study, cytotoxicity tests were performed using -PGA. Our findings show that -PGA exhibits no cytotoxic effects to cell cultures of human hepatoma cells and do not inhibit differentiation in rat skeletal muscle myoblasts. Further studies using an insulin/-PGA complex were inconclusive, but show potential as a time release agent for insulin delivery.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Feijo, Andrea
• Manning, Jonathan Michael

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D107M

Advisor

• Rulfs, Jill
• DiIorio, Alexander A.

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright