The molecular basis for the disease osteopetrosis and its relationship to commonly known diseases of the skeleton like osteoporosis is presented. It is known that colony stimulating factor-1 (CSF-1) can improve osteoclast function and increase their numbers in the tl (toothless) rat model. The technique of differential display was described and used to identify several genes including collagen I (2) which is overexpressed in the mutant tl rat, but not in its CSF-1 treated or normal littermate.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Rodolewicz, John Stanley

Publisher

• Worcester Polytechnic Institute

Identifier

• 99D090M

Advisor

• Adams, David S.

Year

• 1999

Sponsor

• University of Massachusetts Medical School

Date created

• 1999-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright