In this project the effects of a cannabinoid, Ajulemic Acid (AjA), on different types of rheumatoid tissues were studied. Cultured synovial cells, synovial fluid cells and peripheral blood mononucleocytes, were treated with AjA prior to stimulation with TNF-. The results showed a marked decrease in the cytokines Interleukin-6 and Interleukin-8. As both IL-6 and IL-8 play a part in the pathogenesis of rheumatoid arthritis, reduction of their secreted levels could serve as an effective treatment for the disease.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• LeBlanc, Scott Edward
• Paquette, Nicholas Paul

Publisher

• Worcester Polytechnic Institute

Identifier

• 02D530M

Advisor

• Rulfs, Jill

Year

• 2002

Date created

• 2002-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright