Student Work
Effects of ajulemic acid on synoviocytes in vitro
PublicIn this project the effects of a cannabinoid, Ajulemic Acid (AjA), on different types of rheumatoid tissues were studied. Cultured synovial cells, synovial fluid cells and peripheral blood mononucleocytes, were treated with AjA prior to stimulation with TNF-. The results showed a marked decrease in the cytokines Interleukin-6 and Interleukin-8. As both IL-6 and IL-8 play a part in the pathogenesis of rheumatoid arthritis, reduction of their secreted levels could serve as an effective treatment for the disease.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 02D530M
- Advisor
- Year
- 2002
- Date created
- 2002-01-01
- Resource type
- Major
- Rights statement
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