When eukaryotes experience a stressor they produce stress granules due to the activation of the cellular stress response pathway via the phosphorylation of eIF2α. Utilizing acute exposure assays and fluorescent microscopy, stress granule formation was examined in cells that were treated with Resveratrol and other stilbene compounds. It was found that Resveratrol, Piceatannol, Oxyresveratrol, and Pinosylvin cause stress granule formation. Piceatannol was shown to be significantly less efficient in producing stress granules, while Pinosylvin exhibited significantly more stress granule formation.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sorrento, Michaela

Subject

• Health

Publisher

• Worcester Polytechnic Institute

Identifier

• 41071
• E-project-110521-135451

Keyword

• Stress Granules
• Resveratrol
• Stilbenes
• Cellular Stress Response

Advisor

• Farny, Natalie

Year

• 2021

Date created

• 2021-11-05

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved