TYRA-3, A TYRAMINE-ACTIVATED G-PROTEIN COUPLED RECEPTOR, MODULATES LOCOMOTION THROUGH INHIBITION OF DOPAMINERGIC SIGNALING IN CAENORHABDITIS ELEGANSPublic
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TYRA-3 is a tyramine-activated G-protein coupled receptor in C. elegans. TYRA-3 is expressed in dopaminergic ADE and CEP neurons, suggesting it may play a role in modulating dopaminergic signaling. Upon exogenous tyramine exposure, deletion mutants of tyra-3 are more susceptible to paralysis than wild type animals. dat-1 deletion mutants, which contain abnormally high concentrations of synaptic dopamine, were also sensitive to paralysis with tyramine exposure. cat-2 deletion mutants, which contain no dopamine, were partially resistant to tyramine exposure. Double mutants of cat-2;tyra-3 and dat-1;tyra-3 showed moderate sensitivity. These results suggest that TYRA-3 inhibits dopamine release, but additional experiments are necessary to explain the phenotypes of the double mutants.
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