Prostaglandins are an important class of biologically active compounds. The robust syntheses of different prostaglandins are of importance to the pharmaceutical industry. Synthesis should also be able to lead to various analogs. To aid in the development of a robust synthesis, the stereochemistry was controlled with the addition of an acetylenic ester to an aldehyde. The stereochemistry of the other chiral centers can be controlled from the alcohol. Several analogs were produced to demonstrate the validity of the synthesis.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Finnegan, David Francis

Publisher

• Worcester Polytechnic Institute

Identifier

• 01D356M

Advisor

• Dittami, James P.

Year

• 2001

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright