Stem Cell Survey of Human Sebaceous TumorsPublic
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Mutations in stem cell signaling caused by alterations in the Lef1 beta-catenin pathway can lead to the development of sebaceous tumors in humans. A survey of known stem cell markers was conducted on a human sebaceous tumor line and on normal skin using immunoflourescence, PCR and Western Blots to verify the existence of stem cells in sebaceous tumors. The resulting data supports the existence of cancer stem cells in sebaceous tumors.
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