Mutations in stem cell signaling caused by alterations in the Lef1 beta-catenin pathway can lead to the development of sebaceous tumors in humans. A survey of known stem cell markers was conducted on a human sebaceous tumor line and on normal skin using immunoflourescence, PCR and Western Blots to verify the existence of stem cells in sebaceous tumors. The resulting data supports the existence of cancer stem cells in sebaceous tumors.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Barbagallo, Belinda

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042407-183639

Advisor

• Adams, David S.

Year

• 2007

Sponsor

• UMass Medical School

Date created

• 2007-04-24

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved