Alphav Beta6 Integrin Expression in Inflamed & Malignant ProstatePublic
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Prostate cancer cell functions are regulated by elaborate signaling pathways activated by extracellular stimuli. The integrin family of cell surface receptors is known to activate intracellular pathways in response to signals generated via specific interactions with the extracellular matrix. Through the use of immunohistochemistry and immunoblotting, this study shows that the alpha-v beta-6 integrin is predominately expressed in epithelial cells in human preneoplastic, prostate intraepithelial neoplasia, proliferative inflammatory atrophy lesions and prostatic adenocarcinoma. The results indicate that alpha-v beta-6 is highly expressed in areas with infiltrating leukocytes, and is expressed focally in malignant and some benign prostate glands, but not in normal prostate tissue.
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