Comparison of Immunoprotection of Simultaneous to Individual Vaccinations in a Murine ModelPublic
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In response to a viral antigen, the immune system produces epitope-specific T-cells. The majority become cytotoxic T-cells that clear the virus, while a small population remains in memory form to protect against future infections. To determine if multiple, simultaneous infections compromise this protection, mice were immunized with either a single or combination of viruses, then immuno-protection levels were analyzed after a single virus rechallenge by viral titer, viral epitope frequency, and animal weight loss. The results indicate that when immunized against the rechallenge virus, either alone or with another virus, mice receive sufficient protection at day 5. Weight analysis showed that the protection may be dependent upon the viruses used for vaccinations and rechallenge infections.
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