In this project, we used two data mining tools, CBA and WEKA, to search for genetic polymorphisms that affect two human diseases, autosomal recessive spinal muscular atrophy (SMA) and bilateral optic neuropathy (LHON). We modified WEKA to be able to mine genetic data. Our results provided a number of association rules, which identified important genetic variants and phenotypic factors affecting the disease state and severity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Padovano, Bryan William
• Doyle, Daniel Frederick
• Judecki, Jared Paul
• Lund, James Craig

Publisher

• Worcester Polytechnic Institute

Identifier

• 01D346M

Advisor

• Krushkal, Julia S.
• Ryder, Elizabeth F.
• Ruiz, Carolina

Year

• 2001

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology
• Computer Science

Rights statement

• In Copyright