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Designing a Novel 3D In-Vitro Model of Mechanical Stress on Dystrophic Aortic Valve Calcification

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Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the world. Understanding more about the mechanism of CAVD will improve prevention and treatment approaches. The project aimed to design a 3D in-vitro model to investigate the effects of mechanical stress on dystrophic VIC calcification. The design consisted of spheroids embedded in various hydrogels (collagen, fibrin, and GelMA+HAMA), resulting in viable constructs with a range of properties. The constructs were stretched at 10% strain with a cell stimulator (CellSCale MCFX). Further testing should be completed to characterize the interactions between the spheroids and hydrogels and to validate calcification.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • 23321
  • E-project-050621-164637
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Year
  • 2021
Date created
  • 2021-05-06
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Permanent link to this page: https://digital.wpi.edu/show/th83m217s