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Is a precursor to the anti-malarial drug, artemisinin, glycosylated in planta?

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A precursor of the anti-malarial drug, artemisinin (AN), artemisinic acid (AA) can be glycosylated in vitro by suspension cells of A. annua. This project sought to confirm the presence of conjugated AA in whole plants of A. annua. Extracts were hydrolyzed to test for increases in the cleaved terpenoids. Increases were observed in treated shoots after acid hydrolysis and glucosidase treatment, indicating the presence of the conjugates in shoots. AA was not observed after any treatment of root residues.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042706-140250
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  • 2006
Date created
  • 2006-04-27
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Permanent link to this page: https://digital.wpi.edu/show/v979v439s