Phytoestrogens are found in over the counter hormone replacement therapies and may react with the estrogen receptor in a manner similar to estrogen. A strain of MCF7 breast epithelial cells was cultured and assessed using an MTT cell proliferation assay. Assays were performed with combinations of IGF and estrogen to determine estrogen responsiveness. Although the strain of cells was not estrogen responsive, further testing on a different strain could determine how the phytoestrogens affect proliferation rates in comparison to estrogen.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• DeVault, Victoria L.
• Kosmaczewski, Sara Guckian
• Havener, Sarah B.
• Tracy, Sarah B.

贡献者

• Caron, Jess

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042909-131940

Advisor

• Rulfs, Jill
• Buckholt, Michael Allan

Year

• 2009

Date created

• 2009-04-29

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright