Up in smoke -- effects of acute nicotine administration on impulsivity in rats under a paced fixed consecutive number schedule of reinforcementPublic
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Impulsivity is a clinical symptom that has been implicated in numerous psychiatric and neurological disorders. Impulsivity is frequently observed in alcohol and opioid dependence in animal models. This study, in conjunction with UMass Medical School, attempted to extend these findings through the use of varying dosages of nicotine (acute administration) on Wistar Kyoto Rats. The paced Fixed Consecutive Number schedule was utilized to examine a specific component of impulsivity. Impulsivity levels were shown to significantly increase at higher nicotine dosages.
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