Thermo Fisher Scientific is a leading scientific technology company which produces laboratory supplies, equipment, and instruments. Current gravity-fed cell strainers have very slow straining times. The team explored the use of external force to increase the flow rate of the device, while maintaining standard cell yield and viability values. In order to test this, multiple iterations of two different prototypes were made using external force to assist in quicker filtration. Testing was performed using chick embryos at day 10-12 to test for cell yield, viability, and flow rate. The results showed an improvement in flow rate for both prototypes without a loss in cell yield, while the team’s second prototype had a statistically significant loss in cell viability. The team concluded that Thermo Fisher Scientific should move forward with the first prototype due to statistically better cell viability results and ease of use. The prototypes were sent to Thermo Fisher Scientific for further research and development.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Steinman, Jacob S.
• Richard, Rebecca J.
• Lazri, Jon
• Smith, Quillyn
• McCauley, Kelly P.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050321-153845
• 21531

Advisor

• Coburn, Jeannine M
• Sabuncu, Ahmet Can

Year

• 2021

Sponsor

• Thermo Fisher Scientific

Date created

• 2021-05-03

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering
• Mechanical Engineering

Rights statement

• In Copyright

Last modified

• 2021-08-29