Aurora A localization in mouse oocytes is coupled to meiotic spindle integrity: Effects of demecolcine-induced microtubule destabilizationPublic
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The family of ser/thr proteins known as Aurora kinases (Aur) have been shown to play an important role in cell cycle progression in mitotic cells. During meiosis, AurA is required for proper microtubule organization and establishing spindle integrity. This study investigated the effects of demecolcine, a microtubule destabilizing drug, on spindle localization of AurA in activated CF-1 mouse oocytes. Marked differences were observed between controls and demecolcine treated oocytes with respect to the disregulated spatial distribution of AurA.
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