Short periods of ischemia have been shown to protect the heart during future, prolonged ischemic episodes. To isolate factors involved in ischemic preconditioning, New Zealand white rabbit hearts were subjected to episodes of ischemia. The rabbit jejunum was used to assay HPLC fractions of heart effluent. Three factors affecting contractile activity were found: Fraction I, a depressive factor identified as adenosine; Fraction 2, a depressive factor thought to be Met-Enkephalin; and Fraction 3, an excitatory factor suspected to be PGE.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Bergquist, Leya
• Adams, Corey Spencer

Publisher

• Worcester Polytechnic Institute

Identifier

• 02C001M

Advisor

• Ryder, Elizabeth F.

Year

• 2002

Date created

• 2002-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright