Student Work
The Role of 14-3-3-Beta in Regulated DAT Trafficking
PublicDownloadable Content
open in viewerRecent studies from the Melikian Laboratory demonstrate that KCNK3, a potassium channel found in humans, relies on 14-3-3-Beta for PKC stimulated endocytosis. This MQP examined whether or not the dopamine transporter protein (DAT), a related membrane protein, also relies on 14-3-3-Beta for PKC stimulated endocytosis. Data shows that 14-3-3-Beta co-localizes with DAT at the surface of PC12 cells and suggests that 14-3-3-Beta is needed for DAT PKC induced endocytosis to occur in SK-N-MC cells.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Contributors
- Publisher
- Identifier
- E-project-042910-141235
- Advisor
- Year
- 2010
- Sponsor
- Date created
- 2010-04-29
- Resource type
- Major
- Rights statement
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