This study, sponsored by the University of Massachusetts Medical School, examined the relationship between progesterone and gestational hypertension in spontaneously hypertensive heart failure (SHHF) rats. Blood pressure, water consumption, and blood and urine analyses displayed differences between SHHF and normotensive Wistar-Kyoto (WKY) rats. SHHF rats exhibited higher levels of progesterone receptor A in the kidney and lower levels of serum progesterone compared to WKY rats. These differences were associated with the onset of hypertension in pregnant SHHF rats, possibly playing a role in the disease.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Boatright, Naomi Kathleen
• Hicks, Erin Michelle
• Archambault, Elizabeth Z.

Publisher

• Worcester Polytechnic Institute

Identifier

• 03C021M

Advisor

• Cheetham, Ronald D.
• Bagshaw, Joseph C.

Year

• 2003

Sponsor

• University of Massachusetts Medical School

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology
• Biochemistry

Rights statement

• In Copyright