Flt3/Flk2, a receptor tyrosine kinase that is implicated in leukemia, also has an important role in hematopoietic development. This role seems to be most important in the formation of early B cells, evidenced by the observations that this gene is expressed in early B cell progenitors and down-regulated as development progresses and that flk2 gene knockout mice display reduced numbers of B cell progenitors. Thus, the goal of this project is to develop a system in which the gene's biochemical and developmental effects can be studied through reintroducing mutant versions of the gene into doubly deficient (Flt2-/-KitW/Wv) mice using a retroviral vector.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pynn, Michelle Anne
• O'Donnell, Malinda Christene

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D047M

Advisor

• Adams, David S.

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright