Matrix metalloproteinases (MMPs) are a group of complex enzymes known for their role in ECM turnover and homeostasis. These proteinases additionally participate in many other biological processes, but when deregulated contribute to different pathological processes and diseases such as multiple sclerosis and rheumatoid arthritis. Therefore MMPs require tight regulation of their activity. The focus of this project was to gain an understanding of MMPs and to synthesize different novel inhibitors aimed at MMPs and other biological targets.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Isaac, Tamika Taylor

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-011416-093830

Advisor

• Gericke, Arne

Year

• 2016

Center

• Zurich, Switzerland Project Center - MQP

Sponsor

• Zurich University of Applied Sciences

Date created

• 2016-01-14

Location

• Zurich

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright