A distinct alpha9 nicotinic acetylcholine receptor (nAChR) may mediate the inhibition of type II hair cells in the turtle posterior crista. This project aims to localize these nAChRs in the hair cell layer with the use of commercial antibodies and fluorophore-conjugated nicotinic antagonists (e.g., alpha-bungarotoxin). An additional goal has been the optimization and development of protocols for this specific purpose. Identification and visualization of these nAChRs will provide greater insight into the complex neural pharmacology of the inner ear.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sharma, Akanksha

Contributors

• Holt, Joseph C.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-102207-015235

Advisor

• Rulfs, Jill

Year

• 2007

Sponsor

• University of Texas Medical Branch (UTMB)

Date created

• 2007-10-22

Location

• Galveston

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved

Last modified

• 2023-09-19