Hantaviruses cause human diseases throughout the world that range from mild to highly fatal. Evidence suggests that these capillary leak syndromes are mediated by local cytokine production by infiltrating T lymphocytes. Modeling T cell interactions with hantavirus-infected endothelial cells in vitro required the construction of a recombinant adenovirus expressing human HLA B35.01 and evaluation of previously isolated hantavirus-specific T cells. Also, one hantavirus-specific T cell clone was transiently isolated from convalescent patient blood.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Odegard, Jared Mark

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D094M

Advisor

• Rulfs, Jill

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright