The role of MLCK in propranolol activated flux of potassium ions in red blood cells was monitored via a computerized method using ion selective electrodes. An inhibitor specific to MLCK, ML-7, was introduced to a suspension of cells, and propranolol was added. Potassium concentrations were taken for 100 minutes. After treatments of different concentrations of ML-7, inhibition was seen via a decrease in the observed PK values. This discovery leads to the further characterization of the role of MLCK in the proposed mechanism of propranolol activated potassium flux.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Nawrath, Molly S.

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D363M

Advisor

• Hobey, William D.

Year

• 2005

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright

License

• All rights reserved