Tinnitus– affecting ~50 million Americans– is hard to characterize because of its diverse manifestations, which hinder treatment efficacy. Our goal was to further develop a pre-clinical tinnitus characterization assay using reverse correlation, where patients render subjective perceptions from random stimuli. We evaluated stimulus generation methods: an area identified for refinement. The most accurate characterizations came from the Brimijoin Gaussian Smoothed method; 8 segments on a frequency spectrum are systematically filled with a Gaussian-shaped power distribution. This showed statistically significant improvement and had the most positive subjective feedback. In the future, this research may be incorporated into a clinical setting to improve tinnitus treatment via characterization.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Mills, Jacob
• Caplan, Myah

Publisher

• Worcester Polytechnic Institute

Identifier

• 105726
• E-project-042723-050843

Keyword

• Tinnitus
• Reverse Correlation
• Behavioral assay

Advisor

• Lammert, Adam

Year

• 2023

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042723-050843

Rights statement

• In Copyright

Last modified

• 2023-06-18