Effects of Isolation of HIV-1 Envelope Clones from Patient 2044 on Tropism, Co-receptor Use, and Antibody SensitivityPublic
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Interaction with the CD4 co-receptor can change tropism in HIV-1. It has been shown that CCR5-using isolates cultured in vitro without the presence of neutralizing antibodies can be more efficient at infection, while at the same time becoming more sensitive to neutralization. This project studies CXCR4-using envelopes examining the effect of viral isolation on tropism, receptor use, and antibody sensitivity. The cultured CXCR4-using isolates did not evolve different properties from the uncultured CXCR4-using isolate.
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