CTLA-4 is an inhibitory molecule expressed by T-cells that regulates T-cell activation and proliferation. Mice generated to be deficient in CTLA-4 develop a fatal lymphoproliferative disease. This MQP examined the regulation of CTLA-4 deficient T-cells in vivo. This was accomplished by generating radiation chimeric mice with hematopoietic wild-type and CTLA-4-/- cells from congenic mice. These chimeras were examined phenotypically, histologically and functionally. The presence of wild-type T-cells in these animals rescued the CTLA-4-/- T-cells and prevented the lymphoproliferative disorder.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Hodder, Corbin Thomas

Publisher

• Worcester Polytechnic Institute

Identifier

• 01D298M

Advisor

• Adams, David S.

Year

• 2001

Sponsor

• UMass Medical School, Worcester, MA

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright