Immunoregulation of autoreactive CTLA-4 T cells in vivoPublic
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CTLA-4 is an inhibitory molecule expressed by T-cells that regulates T-cell activation and proliferation. Mice generated to be deficient in CTLA-4 develop a fatal lymphoproliferative disease. This MQP examined the regulation of CTLA-4 deficient T-cells in vivo. This was accomplished by generating radiation chimeric mice with hematopoietic wild-type and CTLA-4-/- cells from congenic mice. These chimeras were examined phenotypically, histologically and functionally. The presence of wild-type T-cells in these animals rescued the CTLA-4-/- T-cells and prevented the lymphoproliferative disorder.
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