Student Work
Design of Device to Stretch Tunable Stiffness Substrates for Cell Studies
PublicDownloadable Content
open in viewerThe aim of this project was to design and validate a device to cyclically stretch human cells on tunable stiffness substrates to enable the study of these two mechanical stimuli simultaneously. FEA indicated that squat stretching should yield near pure uniaxial behavior. Polyacrylamide (PA) hydrogel was utilized as the compliant substrate for tissue culture in a temperature controlled, sterile environment. Testing verified that PA gels have sufficient durability in squat configurations and can reach 20% strain at rates up to 10%/sec. This device represents the first method available for mechanobiological studies into the response to combined stretch and stiffness stimuli.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042909-205235
- Advisor
- Year
- 2009
- Date created
- 2009-04-29
- Resource type
- Major
- Rights statement
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Permanent link to this page: https://digital.wpi.edu/show/j96022333