Design and Fabrication of a Novel Cell-Derived Matrix Scaffold for Dermal Wound HealingPublic
Downloadable Contentopen in viewer
Approximately 35 million cases of significant skin loss require clinical intervention annually. Tissue engineering has shown promise in the development of therapies to regenerate full-thickness skin wounds. Here we present the design of a novel cell-derived extracellular matrix scaffold with antimicrobial properties for dermal wound healing. We optimized decellularization methods, cultured dermal fibroblast sheets, cloned a cathelicidin construct, and expressed cathelicidin in a model cell type as steps toward achieving an antimicrobial dermal scaffold with tailored mechanical strength and bioactivity.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Date created
- Resource type
- Rights statement
- Last modified
- In Collection:
Permanent link to this page: https://digital.wpi.edu/show/vd66w162t